A non-hormonal therapy to treat hot flashes and other
symptoms associated with menopause was found to be effective in a recent
The researchers reviewed the experience of 352 women with moderate to severe menopausal vasomotor symptoms, such as hot flashes, who were enrolled in a 12-week study that compared treatment with fezolinetant versus a placebo. The treatment was tested in a range of dosages.
Menopause is associated with vasomotor symptoms which are triggered by neuron activity that affects how the brain regulates temperature. Estrogen helps regulate that activity, but during menopause estrogen levels decline and no longer modulate as effectively.
In this study, more than 80 percent of the women taking fezolinetant reported a reduction in symptoms and more than half of the women taking the treatment indicated a reduction of symptoms of 90 percent or greater.